Carlo Castellani Selected Research

Cystic Fibrosis (Mucoviscidosis)

5/2022	VOCAL: An observational study of ivacaftor for people with cystic fibrosis and selected non-G551D-CFTR gating mutations.
3/2022	Targeting the E1 ubiquitin-activating enzyme (UBA1) improves elexacaftor/tezacaftor/ivacaftor efficacy towards F508del and rare misfolded CFTR mutants.
3/2022	The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs.
1/2022	Clinical outcomes of a large cohort of individuals with the F508del/5T;TG12 CFTR genotype.
9/2021	Pharmacokinetics and pharmacodynamics of antibiotics in cystic fibrosis: a narrative review.
4/2021	Identification of Potential Leukocyte Biomarkers Related to Drug Recovery of CFTR: Clinical Applications in Cystic Fibrosis.
1/2021	Updated guidance on the management of children with cystic fibrosis transmembrane conductance regulator-related metabolic syndrome/cystic fibrosis screen positive, inconclusive diagnosis (CRMS/CFSPID).
8/2020	From Ivacaftor to Triple Combination: A Systematic Review of Efficacy and Safety of CFTR Modulators in People with Cystic Fibrosis.
1/2020	Mental health and cystic fibrosis: Time to move from secondary prevention to predictive medicine.
1/2020	The future of cystic fibrosis care: a global perspective.

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Carlo Castellani Research Topics

Disease

21	Cystic Fibrosis (Mucoviscidosis) 05/2022 - 06/2005
3	Lung Diseases (Lung Disease) 01/2020 - 01/2018
3	Pancreatitis 01/2011 - 07/2003
2	Infections 01/2020 - 02/2016
1	Disease Progression 04/2021
1	Macular Degeneration (Age-Related Maculopathy) 01/2021
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021
1	Malnutrition (Nutritional Deficiencies) 01/2020
1	Persistent Infection 01/2020
1	Pancreatic Diseases (Pancreatic Disease) 10/2019
1	Cysts 01/2017
1	Meconium Ileus 04/2016
1	Pneumothorax 02/2016
1	Respiratory Insufficiency (Respiratory Failure) 02/2016
1	Death (Near-Death Experience) 02/2016
1	Liver Diseases (Liver Disease) 09/2009
1	Pancreatic Neoplasms (Pancreatic Cancer) 12/2006
1	Chronic Pancreatitis 06/2006

Drug/Important Bio-Agent (IBA)

8	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 04/2021 - 07/2003
5	TrypsinogenIBA 10/2019 - 06/2005
4	ivacaftorIBA 05/2022 - 01/2019
3	ChloridesIBA 01/2017 - 06/2005
2	elexacaftorIBA 03/2022 - 03/2022
2	Anti-Bacterial Agents (Antibiotics)IBA 09/2021 - 01/2020
2	TrypsinIBA 10/2007 - 06/2006
2	Kazal Pancreatic Trypsin InhibitorIBA 06/2006 - 07/2003
1	tezacaftor drug combination ivacaftor elexacaftorIBA 03/2022
1	tezacaftorIBA 03/2022
1	ivacaftor drug combination tezacaftorIBA 03/2022
1	Chloride Channels (Chloride Channel)IBA 03/2022
1	Poly TIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 04/2021
1	Pharmaceutical PreparationsIBA 04/2021
1	afliberceptIBA 01/2021
1	Bevacizumab (Avastin)FDA Link 01/2021
1	EnzymesIBA 01/2020
1	Expectorants (Mucolytics)IBA 01/2020
1	ceftazidime drug combination avibactamIBA 11/2019
1	Ceftazidime (Fortum)FDA LinkGeneric 11/2019
1	Trimethoprim (Proloprim)FDA LinkGeneric 11/2019
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 09/2009
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 09/2009
1	alpha 1-Antitrypsin (alpha 1 Antitrypsin)IBA 09/2009
1	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 09/2009
1	Glutathione Transferase (Glutathione S-Transferase)IBA 09/2009
1	Epithelial Sodium ChannelsIBA 07/2009
1	Amiloride (Midamor)FDA LinkGeneric 07/2009
1	Keratin-8 (Keratin 8)IBA 12/2006
1	Codon (Codons)IBA 06/2006

Therapy/Procedure

5	Therapeutics 03/2022 - 01/2019
1	Intravitreal Injections 01/2021
1	High-Protein Diet 01/2020
1	Secondary Prevention 01/2020
1	Precision Medicine 01/2020
1	Terminal Care (Care, Terminal) 01/2018
1	Traction 01/2017
1	Lung Transplantation 02/2016
1	Organ Transplantation 02/2016